Exercise and Cancer
Written by Dr. Mark
I came across this video (https://www.facebook.com/ABCiview/videos/1136919799663997/) which talks about a study that was done in 2013. In the study 10 males were put through varying levels of exercise on stationary bikes. Blood was taken before and after the exercise. The researchers were looking at blood serum levels cells which contribute to your immune system. They then took the pre and post exercise serums and introduced them into prostate cancer cells. The post exercise serum showed a 30% more inhibition of cancer cell tissue growth.
The conclusion, that following intense exercise, there is a systemic, meaning whole body, improvement in immune system function.
It is important to note the researchers distinguished between long tern exercise vs. short term high intensity.
Long-term exercise is known to reduce serum levels of growth stimulating hormones. In contrast, the endocrine effects of acute endurance exercise include increased levels of mitogenic factors such as GH and IGF-1
Basically this is saying long term exercise, such as long duration, low intensity cardio type training, can have a negative affect on growth stimulating hormones and conversely short term high intensity exercise has shown to increase those same hormones. This is not to say, stop running, but instead be sure to add high intensity training into your routine.
Today, my day off (Tuesday) I was able to make it to the gym in the morning, come home and take the new puppy, Kipp, for a walk, and then later in the day play soccer with my kids and Dr. Eric and his daughter. It was a great day full of activity, and I feel great now as I’m sitting her writing this.
Summer is coming, and the kids will be off of school soon. Use that time and your kids to increase your activity. Find an activity that you all enjoy, or even if they don’t like it, just make them. Its great exercise for you and them along with it being great family bonding time, and on top of that you are teaching them to love being active which will set them up for a healthy future.
Link to the research paper referenced in the video: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067579
Abstract from the paper:
Physical activity is associated with reduced risk of several cancers, including aggressive prostate cancer. The mechanisms mediating the effects are not yet understood; among the candidates are modifications of endogenous hormone levels. Long-term exercise is known to reduce serum levels of growth stimulating hormones. In contrast, the endocrine effects ofacute endurance exercise include increased levels of mitogenic factors such as GH and IGF-1. It can be speculated that the elevation of serum growth factors may be detrimental to prostate cancer progression into malignancy. The incentive of the current study is to evaluate the effect of acute exercise serum on prostate cancer cell growth. We designed an exercise intervention where 10 male individuals performed 60 minutes of bicycle exercise at increasing intensity. Serum samples were obtained before (rest serum) and after completed exercise (exercise serum). The established prostate cancer cell line LNCaP was exposed to exercise or rest serum. Exercise serum from 9 out of 10 individuals had a growth inhibitory effect on LNCaP cells. Incubation with pooled exercise serum resulted in a 31% inhibition of LNCaP growth and pre-incubation before subcutaneous injection into SCID mice caused a delay in tumor formation. Serum analyses indicated two possible candidates for the effect; increased levels of IGFBP-1 and reduced levels of EGF. In conclusion, despite the fear of possible detrimental effects of acute exercise serum on tumor cell growth, we show that even the short-term effects seem to add to the overall beneficial influence of exercise on neoplasia.